The Thiruvananthapuram to Salem bus route covers approximately 487 kms and takes about 9 hrs 55 mins. A total of 53 direct buses operated by 22 bus operators run on this route. The first bus departs at 07:00, and the last bus leaves at 22:35.
Major boarding points in Thiruvananthapuram include Aristo Junction, Attingal, Balaramapuram, Chakka Pass, East Thampanoor, Fortis Hospital Cunningham Road, Infosys Campus, Kaliyakavilai, Kaniyapuram,, Kazhakootam, while common drop locations in Salem are Avr Roundana, Kondalampatti, Mallur, Omalur, Others, Salem New Bus Stand, Seelanaickenpatti.
RTC and private operators such as Kallada Travels (Suresh Kallada), JaiSai Roadlinks (JSR), Punchiry Travels and Holidays, Orange Tours And Travels offer Volvo, AC, and non-AC seater and sleeper buses. Ticket prices on redBus range from INR 650 - INR 4408.00 depending on the bus type and features.



