The Thiruvananthapuram to Karaikal bus route covers approximately 553 kms and takes about 12 hrs 39 mins. A total of 7 direct buses operated by 3 bus operators run on this route. The first bus departs at 15:40, and the last bus leaves at 19:00.
Major boarding points in Thiruvananthapuram include Balaramapuram, Infosys Campus, Kazhakootam, Neyyatinkare, Others, Techno Park, Thampanoor, while common drop locations in Karaikal are Karaikal New Bus Stand.
RTC and private operators such as Venky Bus offer Volvo, AC, and non-AC seater and sleeper buses. Ticket prices on redBus range from INR 899 - INR 2078.00 depending on the bus type and features.



