The Thrissur to Udupi bus route covers approximately 406 kms and takes about 9 hrs 8 mins. A total of 18 direct buses operated by 10 bus operators run on this route. The first bus departs at 00:15, and the last bus leaves at 23:50.
Major boarding points in Thrissur include Amala Medical College, Thrissur, KSRTC Bus Stand, Kadavanthara, Kechery, Thrissur, Manuthy Pass, Others, Paliyekkara Toll Gate, Sakthan Thamburan Bus Stand, while common drop locations in Udupi are Ambagilu Bus Stand, Brahmavara Bus Stop, Karavali Bypass, Katapadi, Kaup Marigudi, Padubidri Bus Stop, Service Bus Stand, Taluk Office Udupi, Udyavara Bus Stop.
RTC and private operators such as Kallada Travels (Suresh Kallada), Ubc travels, Blue Bird Travels, Adrin Travels, Kudla Travels ( ST MARIA ) offer Volvo, AC, and non-AC seater and sleeper buses. Ticket prices on redBus range from INR 655 - INR 3000.00 depending on the bus type and features.



