The Thrissur to Kasaragod bus route covers approximately 300 kms and takes about 7 hrs 8 mins. A total of 42 direct buses operated by 16 bus operators run on this route. The first bus departs at 00:00, and the last bus leaves at 23:57.
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Major boarding points in Thrissur include Amala Medical College, Thrissur, KSRTC Bus Stand, Kadavanthara, Kechery, Thrissur, Manuthy Pass, Others, Paliyekkara Toll Gate, Sakthan Thamburan Bus Stand, while common drop locations in Kasaragod are Bandhiyodu, Hosangadi, Kumbala, Thalapadi, Uppala.
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RTC and private operators such as Madhavi Travels, Kallada Travels (Suresh Kallada), Aadithya Travels, Blue Bird Travels, Kudla Travels ( ST MARIA ) offer Volvo, AC, and non-AC seater and sleeper buses. Ticket prices on redBus range from INR 396 - INR 3000.00 depending on the bus type and features.



