The Thodupuzha to Manipal bus route covers approximately 510 kms and takes about 12 hrs 15 mins. A total of 4 direct buses operated by 4 bus operators run on this route. The first bus departs at 19:05, and the last bus leaves at 19:30.
Major boarding points in Thodupuzha include Thodupuzha, Thodupuzha Near Private Busstand, vazhakulam, while common drop locations in Manipal are Bus Stand, Kummaripalem, Tiger Circle.
RTC and private operators such as Kallada Travels (Suresh Kallada), Kudla Travels ( ST MARIA ) offer Volvo, AC, and non-AC seater and sleeper buses. Ticket prices on redBus range from INR 1000 - INR 3000.00 depending on the bus type and features.



