The Ernakulam to Manipal bus route covers approximately 465 kms and takes about 11 hrs 8 mins. A total of 12 direct buses operated by 9 bus operators run on this route. The first bus departs at 19:10, and the last bus leaves at 22:46.
Major boarding points in Ernakulam include Alvvae, Athani (Ekm), Chottanikkara, Edapally, Kalamassery, North Railway Station, Others, Palarivattom, Paravoor Kavala, Thrippunithura, while common drop locations in Manipal are Bus Stand, Indrali Busstop, Kummaripalem, Tiger Circle.
RTC and private operators such as Kallada Travels (Suresh Kallada), Ubc travels offer Volvo, AC, and non-AC seater and sleeper buses. Ticket prices on redBus range from INR 699 - INR 1799.00 depending on the bus type and features.



