The Mannuthy to Salem bus route covers approximately 290 kms and takes about 4 hrs 18 mins. A total of 46 direct buses operated by 25 bus operators run on this route. The first bus departs at 09:15, and the last bus leaves at 23:56.
Major boarding points in Mannuthy include Kadavanthara, Manuthy Pass, while common drop locations in Salem are Avr Roundana, Kondalampatti, Mettupatti, Others, Peramanur, Salem New Bus Stand, Sankagiri, Seelanaickenpatti, Valappadi, Vinayaka Mission University.
RTC and private operators such as Surya Connect, Diya Bus, Kalyani Travels offer Volvo, AC, and non-AC seater and sleeper buses. Ticket prices on redBus range from INR 499 - INR 4999.00 depending on the bus type and features.



