The Manipal to Chennai bus route covers approximately 756 kms and takes about 15 hrs 29 mins. A total of 3 direct buses operated by 2 bus operators run on this route. The first bus departs at 13:00, and the last bus leaves at 21:15.
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Major boarding points in Manipal include Indrali Busstop, Mgm College, Tiger Circle, while common drop locations in Chennai are Anna University, Arumbakkam, Ashok Pillar, Ekkattuthangal, Guindy, Kanchipuram, Koyambedu, Madhya Kailash, Maduravoyal, Navalur.
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RTC and private operators such as Bharathi Travels offer Volvo, AC, and non-AC seater and sleeper buses. Ticket prices on redBus range from INR 1500 - INR 1999.00 depending on the bus type and features.



