The Karaikudi to Bangalore bus route covers approximately 413 kms and takes about 9 hrs 1 mins. A total of 20 direct buses operated by 15 bus operators run on this route. The first bus departs at 11:30, and the last bus leaves at 22:30.
Major boarding points in Karaikudi include Nemathanpatti, New Bus Stand, Sriram Nagar, while common drop locations in Bangalore are Anand Rao Circle, Attibele, BTM Layout, Baiyappanahalli, Bellandur, Bommanahalli, Bommasandra, Central Silk Board, Chamrajpet, Chandapura.
RTC and private operators such as ANNAI TRAVELS, Royal Travels, RKT Tours and Travels, Rithish Travels, Vairam Travels offer Volvo, AC, and non-AC seater and sleeper buses. Ticket prices on redBus range from INR 549 - INR 2999.00 depending on the bus type and features.



