The Salem to Thiruvananthapuram bus route covers approximately 531 kms and takes about 9 hrs 25 mins. A total of 50 direct buses operated by 23 bus operators run on this route. The first bus departs at 00:25, and the last bus leaves at 23:59.
Major boarding points in Salem include Avr Roundana, Kondalampatti, Mallur, Omalur, Salem New Bus Stand, Seelanaickenpatti, Thiruvagoundanur, while common drop locations in Thiruvananthapuram are Aristo Junction, Attingal, Balaramapuram, Chakka Pass, East Thampanoor, Fortis Hospital Cunningham Road, Infosys Campus, Kaniyapuram,, Kazhakootam, Neyyatinkare.
RTC and private operators such as Kallada Travels (Suresh Kallada), JaiSai Roadlinks (JSR), Punchiry Travels and Holidays, VKV Travels offer Volvo, AC, and non-AC seater and sleeper buses. Ticket prices on redBus range from INR 525 - INR 5999.00 depending on the bus type and features.



