The Indore to Itarsi bus route covers approximately 238 kms and takes about 6 hrs 38 mins. A total of 30 direct buses operated by 20 bus operators run on this route. The first bus departs at 04:13, and the last bus leaves at 23:30.
Major boarding points in Indore include Aurbindo Hospital, Bengali Square, Betma, C21 business park, Chandan Nagar Road, Chhotigwaltoli, Dewas, Dewas Naka, Gangwal Bus Stand, Khajrana Square, while common drop locations in Itarsi are Crystal IT Park (Vivekanand Square).
RTC and private operators such as Hans Travels (I) Private Limited, Verma Travels., NeelKamal Bus Service (D.B.S), Atal city skybus om shanti aictsl, Chartered Bus offer Volvo, AC, and non-AC seater and sleeper buses. Ticket prices on redBus range from INR 400 - INR 2300.00 depending on the bus type and features.



