The Indore to Itarsi bus route covers approximately 238 kms and takes about 6 hrs 34 mins. A total of 39 direct buses operated by 24 bus operators run on this route. The first bus departs at 04:13, and the last bus leaves at 23:30.
Major boarding points in Indore include Bengali Square, Best Price Square, Betma, Chandan Nagar Road, Chhotigwaltoli, Gangwal Bus Stand, Indore Junction, Khajrana Square, Mangliya, Navlakha, while common drop locations in Itarsi are Crystal IT Park (Vivekanand Square).
RTC and private operators such as Hans Travels (I) Private Limited, Verma Travels., NeelKamal Bus Service (D.B.S), Atal city skybus om shanti aictsl, Chartered Bus offer Volvo, AC, and non-AC seater and sleeper buses. Ticket prices on redBus range from INR 300 - INR 4000.00 depending on the bus type and features.



