The Vyttila to Salem bus route covers approximately 366 kms and takes about 6 hrs 7 mins. A total of 58 direct buses operated by 33 bus operators run on this route. The first bus departs at 07:33, and the last bus leaves at 23:15.
Major boarding points in Vyttila include Alvvae, Edapally, KSRTC Bus Stand, Kadavanthara, Kalamassery, Kaloor, MG Road, Palarivattom, Paravoor Kavala, South Railway Station, while common drop locations in Salem are Attur, Avr Roundana, Kondalampatti, Omalur, Others, Peramanur, Salem New Bus Stand, Sankagiri, Seelanaickenpatti, Vinayaka Mission University.
RTC and private operators such as Royal Rich India offer Volvo, AC, and non-AC seater and sleeper buses. Ticket prices on redBus range from INR 1199 - INR 4999.00 depending on the bus type and features.



